Ampk and mtor


I have a question concerning the opposing roles of ampk and mtor in protein synthesis.

First, I find this confusing, as exercise increases both ampk and mtor, yet they have opposite effects on protein synthesis. In at least on theory of muscular hypertrophy, protein synthesis is acutely suppressed during exercise (presumably from the increased ampk). Insulin sensitivity is increased from resistance training for some time after, again presumably in part from increased ampk levels. So why doesn’t the increased ampk levels continue to suppress protein synthesis after training? Do they fall below a certain threshold?

More importantly, why would it be a good idea to take a supplement like Indigo (or any drug or supplement, for example, that would increase ampk) at the same time you’re using Micro-PA for increased protein synthesis?

Thanks for the much needed clarification.


Muscle growth is a very complex issue. When you train several things happen that in theory reduces protein synthesis/muscle growth. For example myostatin tend to be activated more when you train with weights… myostatin is what we could call a growth inhibitor (animals devoid of the myostatin genes or with a low expression of the myostatin gene grow muscle at a much much faster rate and reach a super high level of muscularity…see the Belgian Blue bulls). Cortisol also goes up, which while useful for the release of energy during a training session, is also a catabolic hormone which can reduce muscle growth.

In some processes, these “inhibiting factors” are released either to act as an autoregulatory mechanism to avoid and excessive response from the body or can actually be part of the positive response; the body can respond to their release by increasing the release of anabolic factors to a greater degree and the end result is a greater overall anabolic response.

It is a very complex topic and someone like Bill Roberts might provide you with a more complete answer. But when it comes to the body we can’t look at each hormone/messenger involved individually, it’s the whole picture that matters.

INDIGO has a solid impact on muscle insulin sensitivity which will translate into a greater nutrients uptake by the muscles which will have a positive effect on growth. I personally was able to add more muscle mass than usual on INDIGO and MICRO-PA didn’t even exist at the time. And lots of people have reported similar findings this would seem to indicate that the net outcome of the product is an improvement in protein synthesis, not the opposite.


Thanks much for the response. I do still find it confusing why one would use two supplements at the same time, one of which–Indigo (through its ability to raise ampk) specifically reduces the enzyme that the second supplement is designed to raise.

Do you think using a drug that chronically raises ampk would interfere with the effects of Micro-PA?

Would it make any sense to use Micro-PA after training rather than pre-training, in order to avoid the mtor downregulation from exercise and Indigo induced raises in ampk?

Thanks again.


The critcal point here is the degree of AMPK activation. At low degree, such as achieved by exercise, AMPK stimulates insulin sensitivity and protein synthesis. However, when AMPK is highly activated, such as cachexia or other pathophysioligical condition, AMPK inhibits mTOR to reduce protein synthesis.